General Information

    • DRAMP ID

    • DRAMP02778

    • Peptide Name

    • Defensin (Insects, animals)

    • Source

    • Oryctes rhinoceros (Coconut rhinoceros beetle)

    • Family

    • Belongs to the invertebrate defensin family (Type 1 subfamil

    • Gene

    • Not found

    • Sequence

    • AHCLAIGRK

    • Sequence Length

    • 9

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.10561605] Gram-positive bacteria: Staphylococcus aureus (MIC=25 µg/ml), Staphylococcus aureus (MRSA) (MIC>50 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=25 µg/ml), Pseudomonas aeruginosa (MIC>50 µg/ml).

    • Hemolytic Activity

      • [Ref.10561605] Had no hemolytic activity against rabbit erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02778 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02778.

Physicochemical Information

    • Formula

    • C41H73N15O10S

    • Absent Amino Acids

    • DEFMNPQSTVWY

    • Common Amino Acids

    • A

    • Mass

    • 968.19

    • PI

    • 9.51

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +3

    • Boman Index

    • -9.45

    • Hydrophobicity

    • 0.267

    • Aliphatic Index

    • 108.89

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP02778

Comments Information

    • Function

    • Shows very strong activity against Staphylococcus aureus. Has no hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros.

    • Reference

    • Eur. J. Biochem. 1999;266:616-623.

    • Author

    • Ishibashi J, Yang J, Saido-Sakanaka H, Nakazawa H, Yamamoto M, Yamakawa M.