General Information

    • DRAMP ID

    • DRAMP02789

    • Peptide Name

    • Tenecin-1 (Insects, animals)

    • Source

    • Tenebrio molitor (Yellow mealworm beetle)

    • Family

    • Belongs to the invertebrate defensin family (Type 1 subfamily)

    • Gene

    • Not found

    • Sequence

    • VTCDILSVEAKGVKLNDAACAAHCLFRGRSGGYCNGKRVCVCR

    • Sequence Length

    • 43

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02789 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02789.

Physicochemical Information

    • Formula

    • C189H316N62O56S6

    • Absent Amino Acids

    • MPQW

    • Common Amino Acids

    • C

    • Mass

    • 4545.33

    • PI

    • 8.92

    • Basic Residues

    • 8

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +5

    • Boman Index

    • -63.74

    • Hydrophobicity

    • 0.179

    • Aliphatic Index

    • 81.63

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 44.4

    • Polar Residues

    • 17

DRAMP02789

DRAMP02789 chydropathy plot

Comments Information

    • Function

    • Bactericidal protein produced in response to injury. It is cytotoxic to Gram-positive bacteria.

    • PTM

    • Contains three disulfide bonds.

Literature Information

  • ·Literature 1

    • Title

    • Purification and molecular cloning of cDNA for an inducible antibacterial protein from larvae of the coleopteran, Tenebrio molitor.

    • Reference

    • J. Biochem. 1994; 116:53-58

    • Author

    • Moon HJ, Lee SY, Kurata S, Natori S, Lee BL.