General Information

    • DRAMP ID

    • DRAMP02790

    • Peptide Name

    • Tenecin-3 (Insects, animals)

    • Source

    • Tenebrio molitor (Yellow mealworm beetle)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DHHDGHLGGHQTGHQGGQQGGHLGGQQGGHLGGHQGGQPGGHLGGHQGGIGGTGGQQHGQHGPGTGAGHQGGYKTHGH

    • Sequence Length

    • 78

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02790 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02790.

Physicochemical Information

    • Formula

    • C305H446N122O101

    • Absent Amino Acids

    • CEFMNRSVW

    • Common Amino Acids

    • G

    • Mass

    • 7437.65

    • PI

    • 7.02

    • Basic Residues

    • 16

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +14

    • Boman Index

    • -116.96

    • Hydrophobicity

    • -1.331

    • Aliphatic Index

    • 26.28

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 19.35

    • Polar Residues

    • 39

DRAMP02790

DRAMP02790 chydropathy plot

Comments Information

    • Function

    • Antifungal heat stable protein produced in response to injury. It is active against C.albicans. No antibacterial activity against Gram-positive and Gram-negative bacteria.

    • Developmental stage

    • Highest expression in larvae and adult. To a much lesser extent in pupae.

Literature Information

  • ·Literature 1

    • Title

    • Structure and expression of the tenecin 3 gene in Tenebrio molitor.

    • Reference

    • Biochem Biophys Res Commun. 1996 Jan 5;218(1):6-11.

    • Author

    • Lee YJ, Chung TJ, Park CW, Hahn Y, Chung JH, Lee BL, Han DM, Jung YH, Kim S, Lee Y.
  • ·Literature 2

    • Title

    • Biochemical and molecular characterization of an antifungal protein from Tenebrio molitor larvae.

    • Reference

    • Mol. Cells 1995;5:287-292.

    • Author

    • Jung HY, Park BY, Lee DK, Hahn Y, Chung JH, Han DM, Moon HJ, Lee BL, Lee Y.