General Information

    • DRAMP ID

    • DRAMP02801

    • Peptide Name

    • Lysozyme C, spleen isozyme (1,4-beta-N-acetylmuramidase C; houses, mammals, animals)

    • Source

    • Equus caballus (Horse)

    • Family

    • Belongs to the glycosyl hydrolase 22 family

    • Gene

    • Not found

    • Sequence

    • KVFERXELARTLKRLGLDGFRGVSLPNXVXLAR

    • Sequence Length

    • 33

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02801 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02801.

Physicochemical Information

    • Formula

    • C153H254N48O37

    • Absent Amino Acids

    • CHIMQWY

    • Common Amino Acids

    • L

    • Mass

    • 3746.04

    • PI

    • 11.44

    • Basic Residues

    • 7

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +4

    • Boman Index

    • -66.61

    • Hydrophobicity

    • -0.121

    • Aliphatic Index

    • 103.33

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP02801

DRAMP02801 chydropathy plot

Comments Information

    • Function

    • Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents By similarity.

    • Catalytic activity

    • Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    • Miscellaneous

    • Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides By similarity.

Literature Information

  • ·Literature 1

    • Title

    • Sequences of two highly divergent canine type c lysozymes: implications for the evolutionary origins of the lysozyme/alpha-lactalbumin superfamily.

    • Reference

    • Arch Biochem Biophys. 1994 Sep;313(2):360-366.

    • Author

    • Grobler JA, Rao KR, Pervaiz S, Brew K.