General Information

    • DRAMP ID

    • DRAMP02804

    • Peptide Name

    • Mytilus defensin-B (molluscas, animals)

    • Source

    • Mytilus edulis (Blue mussel)

    • Family

    • Belongs to the invertebrate defensin family (Type 2 subfamily)

    • Gene

    • Not found

    • Sequence

    • GFGCPNDYPCHRHCKSIPGRYGGYCGGXHRLRCTC

    • Sequence Length

    • 35

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacterium: Micrococcus luteus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02804 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02804.

Physicochemical Information

    • Formula

    • C158H234N54O42S6

    • Absent Amino Acids

    • AEMQVW

    • Common Amino Acids

    • G

    • Mass

    • 3883.64

    • PI

    • 8.92

    • Basic Residues

    • 8

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +7

    • Boman Index

    • -73.88

    • Hydrophobicity

    • -0.726

    • Aliphatic Index

    • 22.29

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 4845

    • Absorbance 280nm

    • 142.5

    • Polar Residues

    • 19

DRAMP02804

DRAMP02804 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity.

Literature Information

  • ·Literature 1

    • Title

    • Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis.

    • Reference

    • J Biol Chem. 1996 Sep 6;271(36):21808-21813.

    • Author

    • Charlet M, Chernysh S, Philippe H, Hetru C, Hoffmann JA, Bulet P.