General Information

    • DRAMP ID

    • DRAMP02813

    • Peptide Name

    • Conolysin-Mt1

    • Source

    • Conus mustelinus (Weasel cone)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FHPSLWVLIPQYIQLIRKILKSG

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Ref.17927208]Gram-positive bacterium: Staphylococcus aureus (MIC=25-50 µM);
      • Gram-positive bacterium: Escherichia coli (MIC>50 µM).

    • Hemolytic Activity

      • [Ref.17927208]95% hemolytic activity at 25 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02813 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02813.

Physicochemical Information

    • Formula

    • C134H213N33O29

    • Absent Amino Acids

    • ACDEMNT

    • Common Amino Acids

    • IL

    • Mass

    • 2750.37

    • PI

    • 10.29

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +4

    • Boman Index

    • 0.95

    • Hydrophobicity

    • 0.448

    • Aliphatic Index

    • 148.26

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 317.73

    • Polar Residues

    • 4

DRAMP02813

DRAMP02813 chydropathy plot

Comments Information

    • Function

    • This cytolytic peptide has ability to disrupt the integrity of cell membranes from both prokaryotes and eukaryotes. It permeabilizes both negatively charged prokaryotic (PE

    • Tissue specificity

    • Expressed by the venom duct.

    • Miscellaneous

    • The mature peptide does not contain cysteine residue. Mt1 and Mt2 peptides are found in a ratio of 1

Literature Information

  • ·Literature 1

    • Title

    • Conolysin-Mt: a conus peptide that disrupts cellular membranes.

    • Reference

    • Biochemistry. 2007 Nov 6;46(44):12586-12593.

    • Author

    • Biggs J.S, Rosenfeld Y, Shai Y, Olivera B.M.