General Information

    • DRAMP ID

    • DRAMP02820

    • Peptide Name

    • Holotricin-1 (Gly-rich; His-rich; invertebrate defensin; animals)

    • Source

    • Holotrichia diomphalia (Korean black chafer)

    • Family

    • Belongs to the invertebrate defensin family (Type 1 subfamily)

    • Gene

    • Not found

    • Sequence

    • VTCDLLSLQIKGIAINDSACAAHCLAMRRKGGSCKQGVCVCRN

    • Sequence Length

    • 43

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02820 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02820.

Physicochemical Information

    • Formula

    • C184H321N61O56S7

    • Absent Amino Acids

    • EFPWY

    • Common Amino Acids

    • C

    • Mass

    • 4508.37

    • PI

    • 8.94

    • Basic Residues

    • 7

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +5

    • Boman Index

    • -51.24

    • Hydrophobicity

    • 0.305

    • Aliphatic Index

    • 95.35

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 8.93

    • Polar Residues

    • 16

DRAMP02820

DRAMP02820 chydropathy plot

Comments Information

    • Function

    • Shows potent antibacterial activity against Gram-positive bacteria.

    • PTM

    • Contians three disulfide bonds 3-34; 20-39; 24-41.

Literature Information

  • ·Literature 1

    • Title

    • A sapecin homologue of Holotrichia diomphalia: purification, sequencing and determination of disulfide pairs.

    • Reference

    • Biol Pharm Bull. 1995 Mar;18(3):457-459.

    • Author

    • Lee S.Y, Moon H.J, Kawabata S, Kurata S, Natori S, Lee B.L.