• DRAMP ID

    • DRAMP02821
    • Peptide Name

    • Holotricin-2 (Gly-rich; His-rich; invertebrate defensin; animals)
    • Source

    • Holotrichia diomphalia (Korean black chafer)
    • Family

    • Belongs to the coleoptericin family
    • Gene

    • Not found
    • Sequence

    • SLQPGAPSFPMPGSQLPTSVSGNVEKQGRNTIATIDAQHKTDRYDVRGTWTKVVDGPGRSKPNFRIGGSYRW
    • Sequence Length

    • 72
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02821 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02821.
    • Formula

    • C344H539N105O105S
    • Absent Amino Acids

    • C
    • Common Amino Acids

    • G
    • Mass

    • 7857.76
    • PI

    • 10.27
    • Basic Residues

    • 11
    • Acidic Residues

    • 5
    • Hydrophobic Residues

    • 17
    • Net Charge

    • +6
    • Boman Index

    • -167.99
    • Hydrophobicity

    • -0.858
    • Aliphatic Index

    • 51.39
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 13980
    • Absorbance 280nm

    • 196.9
    • Polar Residues

    • 27

DRAMP02821

DRAMP02821 chydropathy plot
    • Function

    • Antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria.
  • ·Literature 1
    • Title

    • Purification and molecular cloning of cDNA for an inducible antibacterial protein of larvae of a coleopteran insect, Holotrichia diomphalia.
    • Reference

    • J Biochem. 1994 Jan;115(1):82-86.
    • Author

    • Lee SY, Moon HJ, Kurata S, Kurama T, Natori S, Lee BL.