General Information

    • DRAMP ID

    • DRAMP02828

    • Peptide Name

    • BMAP-34 (BMAP 34, bovine cathelicidin, cattle, ruminant, mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the cathelicidin family.

    • Gene

    • CATHL7

    • Sequence

    • GLFRRLRDSIRRGQQKILEKARRIGERIKDIFRG

    • Sequence Length

    • 34

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.9795251] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3 μM), Staphylococcus aureus Cowan 1 (MIC=3 μM), Staphylococcus aureus (MRSA, clinical isolate) (MIC=6 μM), Staphylococcus epidermidis ATCC 12228 (MIC=1.5 μM), Bacillus megaterium Bm 11 (MIC=3 μM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1.5 μM), Escherichia coli ML-35 (MIC=1.5 μM), Escherichia coli D21 (MIC=1.5 μM), Escherichia coli D22 (MIC=1.5 μM), Salmonella typhimurium ATCC 14028 (MIC=3 μM), Salmonella enteritidis (clinical isolate) (MIC=3 μM), Serratia marcescens ATCC 8100 (MIC=1.5 μM), Pseudomonas aeruginosa ATCC 27853 (MIC≥48 μM);
      • Fungus: Candida albicans (clinical isolate) (MIC>96 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02828 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C180H314N66O46

    • Absent Amino Acids

    • CHMNPTVWY

    • Common Amino Acids

    • R

    • Mass

    • 4138.89

    • PI

    • 11.91

    • Basic Residues

    • 12

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +8

    • Boman Index

    • -145.58

    • Hydrophobicity

    • -1.009

    • Aliphatic Index

    • 94.71

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP02828

DRAMP02828 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.

    • Tissue specificity

    • Expressed in bone marrow myeloid cells, spleen and testis.

Literature Information

  • ·Literature 1

    • Title

    • Structural organization of the bovine cathelicidin gene family and identification of a novel member.

    • Reference

    • FEBS Lett. 1997 Nov 17;417(3):311-5.

    • Author

    • Scocchi M, Wang S, Zanetti M.
  • ·Literature 2

    • Title

    • Biological characterization of a novel mammalian antimicrobial peptide.

    • Reference

    • Biochim Biophys Acta. 1998 Oct 23;1425(2):361-368.

    • Author

    • Gennaro R, Scocchi M, Merluzzi L, Zanetti M.