General Information

    • DRAMP ID

    • DRAMP02842

    • Peptide Name

    • LfcinB(20-25)

    • Source

    • bovine

    • Family

    • bovine LfcinB

    • Gene

    • LTF

    • Sequence

    • RRWQWR

    • Sequence Length

    • 6

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Ref.29984236] Gram-positive bacterium: Staphylococcus aureus ATCC 33591 (MIC=100 μg/ml; MBC=199 μg/ml)

    • Hemolytic Activity

      • [Ref.29984236] 3% hemolysis at 5 μM, 5% hemolysis at 12 μM, 5% hemolysis at 22 μM, 0% hemolysis at 50 μM, 2% hemolysis at 100 μM against human red blood cell.
      • [Ref.29551999] 7.1% hemolysis at 25μM, 50% hemolysis at >100μM against human red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02842 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP02842.

Physicochemical Information

    • Formula

    • C45H66N18O8

    • Absent Amino Acids

    • ACDEFGHIKLMNPSTVY

    • Common Amino Acids

    • R

    • Mass

    • 987.13

    • PI

    • 12.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +3

    • Boman Index

    • -45.64

    • Hydrophobicity

    • -3.133

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 2200

    • Polar Residues

    • 0

DRAMP02842

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens.

    • Reference

    • Biomed Res Int. 2018 Jun 10;2018:5252891

    • Author

    • Sandra C. Vega Chaparro, J. Tatiana Valencia Salguero, Diana A. Mart
  • ·Literature 2

    • Title

    • Design, Synthesis and Evaluation of Branched RRWQWR-Based Peptides as Antibacterial Agents against Clinically Relevant Gram-Positive and Gram-Negative Pathogens

    • Reference

    • Front Microbiol. 2018 Mar 2;9:329.

    • Author

    • Nguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ
  • ·Literature 3

    • Title

    • Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs

    • Reference

    • PLoS One. 2010 Sep 10;5(9):e12684. doi: 10.1371/journal.pone.0012684

    • Author