General Information

    • DRAMP ID

    • DRAMP02845

    • Peptide Name

    • CP-11 (cathelicidin; mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ICLKKWPWWPWRRCKX

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=16 µg/ml), Pseudomonas aeruginosa (MIC=64 µg/ml), Salmonella typhimurium(MIC=64 µg/ml), S. typhimurium defensin sensitive (MIC=4 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=16 µg/ml), Staphylococcus aureus (MRSA) (MIC=16 µg/ml), S. epidermidis(MIC=8 µg/ml), Enterococcus faecalis (MIC=64 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Non helix or strand structure

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02845 helical wheel diagram

    • PDB ID

    • 1QX9 resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP02845.

Physicochemical Information

    • Formula

    • C102H146N28O15S2

    • Absent Amino Acids

    • ADEFGHMNQSTVY

    • Common Amino Acids

    • W

    • Mass

    • 2197.93

    • PI

    • 10.33

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +5

    • Boman Index

    • -24.77

    • Hydrophobicity

    • -0.888

    • Aliphatic Index

    • 48.75

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 22125

    • Absorbance 280nm

    • 1475

    • Polar Residues

    • 2

DRAMP02845

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.

    • Reference

    • Biochemistry. 2000 Dec 26;39(51):15765-15774.

    • Author

    • Rozek A, Friedrich CL, Hancock RE.
  • ·Literature 2

    • Title

    • Structure-based design of an indolicidin peptide analogue with increased protease stability.

    • Reference

    • Biochemistry. 2003 Dec 9;42(48):14130-14138.

    • Author

    • Rozek, A.; Powers, JP.; Friedrich, CL.; Hancock, RE.