General Information

    • DRAMP ID

    • DRAMP02846

    • Peptide Name

    • Secretolytin (mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the chromogranin/secretogranin protein family

    • Gene

    • CHGB

    • Sequence

    • QKIAEKFSGTRRG

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02846 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02846.

Physicochemical Information

    • Formula

    • C63H108N22O19

    • Absent Amino Acids

    • CDHLMNPVWY

    • Common Amino Acids

    • GKR

    • Mass

    • 1477.69

    • PI

    • 11

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +3

    • Boman Index

    • -47.67

    • Hydrophobicity

    • -1.308

    • Aliphatic Index

    • 37.69

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02846

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial activity of secretolytin, a chromogranin B-derived peptide (614-626), is correlated with peptide structure.

    • Reference

    • Eur J Biochem. 1995 Apr 15;229(2):356-368.

    • Author

    • Strub JM, Hubert P, Nullans G, Aunis D, Metz-Boutigue MH.
  • ·Literature 2

    • Title

    • Processing of chromogranin B in bovine adrenal medulla. Identification of secretolytin, the endogenous C-terminal fragment of residues 614-626 with antibacterial activity.

    • Reference

    • FEBS Lett. 1996 Feb 5;379(3):273-278.

    • Author

    • Strub JM, Garcia-Sablone P, Lonning K, Taupenot L, Hubert P, Van Dorsselaer A, Aunis D, Metz-Boutigue MH.