General Information

    • DRAMP ID

    • DRAMP02851

    • Peptide Name

    • Cathelicidin-1 (Bactenecin-1, Bac1; Cyclic dodecapeptide; mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • CATHL1

    • Sequence

    • RLCRIVVIRVCR

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=1-8 µg/ml);
      • Gram-negative bacterium: Escherichia coli (MIC=8-25 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys3 and Cys11.

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Three disulfide bonds.

    • Helical Wheel Diagram

    • DRAMP02851 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02851.

Physicochemical Information

    • Formula

    • C63H120N24O13S2

    • Absent Amino Acids

    • ADEFGHKMNPQSTWY

    • Common Amino Acids

    • R

    • Mass

    • 1485.92

    • PI

    • 11.53

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -30.24

    • Hydrophobicity

    • 1.033

    • Aliphatic Index

    • 170

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 11.36

    • Polar Residues

    • 2

DRAMP02851

Comments Information

    • Function

    • Potent microbicidal activity; active against S.aureus and E.coli.

    • Tissue specificity

    • Large granules of neutrophils.

    • PTM

    • Contains three disulfide bonds.

Literature Information

  • ·Literature 1

    • Title

    • Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils.

    • Reference

    • J Biol Chem. 1988 Jul 15;263(20):9573-9575.

    • Author

    • Romeo D, Skerlavaj B, Bolognesi M, Gennaro R.