General Information

    • DRAMP ID

    • DRAMP02853

    • Peptide Name

    • Cathelicidin-3 (Bactenecin-7, Bac7; PR-59; mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • CATHL3

    • Sequence

    • RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRP

    • Sequence Length

    • 59

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02853 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP02853.

Physicochemical Information

    • Formula

    • C323H526N110O60

    • Absent Amino Acids

    • ACDEHKMNQSTVWY

    • Common Amino Acids

    • P

    • Mass

    • 6910.43

    • PI

    • 13.2

    • Basic Residues

    • 17

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +17

    • Boman Index

    • -202.52

    • Hydrophobicity

    • -1.371

    • Aliphatic Index

    • 52.88

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP02853

DRAMP02853 chydropathy plot

Comments Information

    • Function

    • Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms.

    • Tissue specificity

    • Large granules of neutrophils.

    • PTM

    • Contains two disulfide bonds.

Literature Information

  • ·Literature 1

    • Title

    • Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils.

    • Reference

    • J Biol Chem. 1990 Nov 5;265(31):18871-18874.

    • Author

    • Frank RW, Gennaro R, Schneider K, Przybylski M, Romeo D.