General Information

    • DRAMP ID

    • DRAMP02872

    • Peptide Name

    • Myeloid antimicrobial peptide BMAP-27 (1-18) (mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GRFKRFRKKFKKLFKKLS

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 µM), Escherichia coli ML35 (MIC=4 µM), Escherichia coli D21 (MIC=4 µM), Salmonella typhimurium ATCC 14028 (MIC=4 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=1 µM), Serratia marcescens ATCC 8100 (MIC=2 µM);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 µM), Staphylococcus aureus Cowan 1 (MIC=2 µM), Staphylococcus aureus (MRSA) (MIC=4 µM), Staphylococcus epidermidis ATCC 12228 (MIC=1 µM), Bacillus megaterium Bm11 (MIC=2 µM).
      • Fungi: Candida albicans (MIC=16 µM), Cryptococcus neoformans (MIC=4 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02872 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C113H188N34O20

    • Absent Amino Acids

    • ACDEHIMNPQTVWY

    • Common Amino Acids

    • K

    • Mass

    • 2342.95

    • PI

    • 12.32

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +10

    • Boman Index

    • -64.31

    • Hydrophobicity

    • -1.289

    • Aliphatic Index

    • 43.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP02872

DRAMP02872 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity.

Literature Information

  • ·Literature 1

    • Title

    • Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.

    • Reference

    • J Biol Chem. 1996 Nov 8;271(45):28375-28381.

    • Author

    • Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.