• DRAMP ID

    • DRAMP02873
    • Peptide Name

    • Myeloid antimicrobial peptide BMAP-28 (1-18) (mammals, animals)
    • Source

    • Bos taurus (Bovine)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GGLRSLGRKILRAWKKYG
    • Sequence Length

    • 18
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 µM), Escherichia coli ML35 (MIC=0.5 µM), Escherichia coli D21 (MIC=0.5 µM), Salmonella typhimurium ATCC14028 (MIC=2 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=1 µM), Serratia marcescens ATCC 8100 (MIC=2 µM);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 µM), Staphylococcus aureus Cowan 1 (MIC=1 µM), Staphylococcus aureus (MIC=4 µM), Staphylococcus epidermidis ATCC 12228 (MIC=1 µM), Bacillus megaterium Bm11 (MIC=2 µM).
      • Fungi: Candida albicans (MIC=16 µM), Cryptococcus neoformans (MIC=2 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02873 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C94H159N31O21
    • Absent Amino Acids

    • CDEFHMNPQTV
    • Common Amino Acids

    • G
    • Mass

    • 2059.49
    • PI

    • 11.74
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Net Charge

    • +6
    • Boman Index

    • -37.37
    • Hydrophobicity

    • -0.672
    • Aliphatic Index

    • 92.22
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 6990
    • Absorbance 280nm

    • 411.18
    • Polar Residues

    • 6

DRAMP02873

DRAMP02873 chydropathy plot
    • Function

    • Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity.
  • ·Literature 1
    • Title

    • Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.
    • Reference

    • J Biol Chem. 1996 Nov 8;271(45):28375-28381.
    • Author

    • Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.