General Information

    • DRAMP ID

    • DRAMP02877

    • Peptide Name

    • mBMAP28 (mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GGLRSLGRKILRAWKKYGPQATPATRQ

    • Sequence Length

    • 27

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 µM), Escherichia coli ML35 (MIC=0.5 µM), Salmonella typhimurium ATCC 14028 (MIC=1 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=0.5 µM), Serratia marcescens ATCC 8100 (MIC=4 µM).
      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8 µM), Staphylococcus aureus (MRSA) (MIC>64 µM), Staphylococcus epidermidis ATCC 12228 (MIC=2 µM), Bacillus megaterium Bm11 (MIC=2 µM).
      • Fungi: Candida albicans (MIC=8 µM), Cryptococcus neoformans (MIC=4 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02877 helical wheel diagram

    • Predicted Structure

Physicochemical Information

    • Formula

    • C134H225N45O34

    • Absent Amino Acids

    • CDEFHMNV

    • Common Amino Acids

    • GR

    • Mass

    • 3010.54

    • PI

    • 12.02

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +7

    • Boman Index

    • -64.89

    • Hydrophobicity

    • -0.911

    • Aliphatic Index

    • 68.89

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 268.85

    • Polar Residues

    • 8

DRAMP02877

DRAMP02877 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.

    • Reference

    • J. Biol. Chem. 1996; 271:28375-28381

    • Author

    • Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.1996