• DRAMP ID

    • DRAMP02909
    • Peptide Name

    • Beta-defensin 2 (BD-2; sBD-2; mammals, animals)
    • Source

    • Ovis aries (Sheep)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • DEFB2
    • Sequence

    • HGVTDSLSCRWKKGICVLTRCPGTMRQIGTCFGPPVKCCRLK
    • Sequence Length

    • 42
    • Protein Existence

    • Homology
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02909 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02909.
    • Formula

    • C198H332N62O52S7
    • Absent Amino Acids

    • AENY
    • Common Amino Acids

    • C
    • Mass

    • 4637.62
    • PI

    • 9.61
    • Basic Residues

    • 9
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +8
    • Boman Index

    • -61.12
    • Hydrophobicity

    • -0.076
    • Aliphatic Index

    • 67.14
    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5875
    • Absorbance 280nm

    • 143.29
    • Polar Residues

    • 17

DRAMP02909

DRAMP02909 chydropathy plot
    • Function

    • Has bactericidal activity (By similarity).
  • ·Literature 1
    • Title

    • Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract.
    • Reference

    • J Nutr. 1998 Feb;128(2 Suppl):297S-299S.
    • Author

    • Huttner K.M, Brezinski-Caliguri D.J, Mahoney M.M, Diamond G.
  • ·Literature 2
    • Title

    • Localization and genomic organization of sheep antimicrobial peptides genes.
    • Reference

    • Gene. 1998 Jan 5;206(1):85-91.
    • Author

    • Huttner K.M, Lambeth M.R, Burkin H.R, Broad T.E.