General Information

    • DRAMP ID

    • DRAMP02910

    • Peptide Name

    • Ovispirin-2 (OV-2; mammals, animals)

    • Source

    • Ovis aries (Sheep)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LRRIIRKIIHIIKK

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Pseudomonas aeruginosa (MIC=0.03-16 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02910 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02910.

Physicochemical Information

    • Formula

    • C84H158N28O15

    • Absent Amino Acids

    • ACDEFGMNPQSTVWY

    • Common Amino Acids

    • I

    • Mass

    • 1800.36

    • PI

    • 12.31

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +7

    • Boman Index

    • -31.63

    • Hydrophobicity

    • 0.171

    • Aliphatic Index

    • 195

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP02910

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis.

    • Reference

    • Antimicrob Agents Chemother. 2001 Oct;45(10):2838-2844.

    • Author

    • Saiman L, Tabibi S, Starner TD, San Gabriel P, Winokur PL, Jia HP, McCray PB Jr, Tack BF.