General Information

    • DRAMP ID

    • DRAMP02913

    • Peptide Name

    • SMAP-34 (cathelicidin; mammals, animals)

    • Source

    • Ovis aries (Sheep)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFGRLRDSLQRGGQKILEKAERIWCKIKDIFRG

    • Sequence Length

    • 34

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

      • [Ref.10768969][No NaCl]: Escherichia coli DH5a (MIC=0.5 μM), Escherichia coli ML-35p (MIC=1.93 μM), Pseudomonas aeruginosa PAO1 (MIC=0.6 μM), Pseudomonas aeruginosa MR3007 (MIC=2 μM), Staphylococcus aureus ATCC (MRSA) 33591 (MIC=4 μM), Staphylococcus aureus 93918 (MIC=1.96 μM).100 mM NaCl: Escherichia coli DH5a (MIC=0.23 μM), Escherichia coli ML-35p (MIC=1.03 μM), Pseudomonas aeruginosa PAO1 (MIC=0.77 μM), Pseudomonas aeruginosa MR3007 (MIC=1.9 μM), Staphylococcus aureus ATCC (MRSA) 33591 (MIC=13.3 μM), Staphylococcus aureus 93918 (MIC=2.13 μM).

    • Hemolytic Activity

      • [Ref.10768969]30% hemolysis at 1000 μg/ml against human red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02913 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02913.

Physicochemical Information

    • Formula

    • C178H296N56O46S

    • Absent Amino Acids

    • HMNPTVY

    • Common Amino Acids

    • GR

    • Mass

    • 3988.72

    • PI

    • 10.43

    • Basic Residues

    • 9

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +5

    • Boman Index

    • -86.9

    • Hydrophobicity

    • -0.579

    • Aliphatic Index

    • 94.71

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 166.67

    • Polar Residues

    • 7

DRAMP02913

DRAMP02913 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity.

Literature Information

  • ·Literature 1

    • Title

    • Bactericidal activity of mammalian cathelicidin-derived peptides.

    • Reference

    • Infect Immun. 2000 May;68(5):2748-2755.

    • Author

    • Travis SM, Anderson NN, Forsyth WR, Espiritu C, Conway BD, Greenberg EP, McCray PB Jr, Lehrer RI, Welsh MJ, Tack BF.