General Information

    • DRAMP ID

    • DRAMP02914

    • Peptide Name

    • Cathelicidin-1 (Bactenecin-1, Bac1; Cyclic dodecapeptide; ma

    • Source

    • Ovis aries (Sheep)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • CATHL1A

    • Sequence

    • RICRIIFLRVCR

    • Sequence Length

    • 12

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus;
      • Gram-negative bacterium: Escherichia coli.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02914 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02914.

Physicochemical Information

    • Formula

    • C68H122N24O13S2

    • Absent Amino Acids

    • ADEGHKMNPQSTWY

    • Common Amino Acids

    • R

    • Mass

    • 1547.99

    • PI

    • 11.53

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -30.42

    • Hydrophobicity

    • 0.942

    • Aliphatic Index

    • 154.17

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 11.36

    • Polar Residues

    • 2

DRAMP02914

Comments Information

    • Function

    • Potent microbicidal activity; active against S. aureus and E. coli (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • cDNA sequences of three sheep myeloid cathelicidins.

    • Reference

    • FEBS Lett. 1995 Dec 4;376(3):225-228.

    • Author

    • Bagella L, Scocchi M, Zanetti M.
  • ·Literature 2

    • Title

    • Localization and genomic organization of sheep antimicrobial peptide genes.

    • Reference

    • Gene. 1998 Jan 5;206(1):85-91.

    • Author

    • Huttner KM, Lambeth MR, Burkin HR, Burkin DJ, Broad TE.