General Information
-
DRAMP ID
- DRAMP02915
-
Peptide Name
- Cathelicidin-2 (Bactenecin-5, Bac5; OaBac5; mammals, animals)
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Source
- Ovis aries (Sheep)
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Family
- Belongs to the cathelicidin family
-
Gene
- CATHL2
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Sequence
- RFRPPIRRPPIRPPFRPPFRPPVRPPIRPPFRPPFRPPIGPFP
-
Sequence Length
- 43
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Lipipolysaccharides (LPS)-binding
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02915.
Physicochemical Information
-
Formula
- C251H384N76O44
Absent Amino Acids
- ACDEHKLMNQSTWY
Common Amino Acids
- P
Mass
- 5170.29
PI
- 13
Basic Residues
- 11
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +11
-
Boman Index
- -121.58
Hydrophobicity
- -0.998
Aliphatic Index
- 43.02
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP02915
![DRAMP02915 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP02915.1.png)
Comments Information
Function
- Has potent antimicrobial activity (By similarity).
Literature Information
- ·Literature 1
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Title
- Localization and genomic organization of sheep antimicrobial peptide genes.
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Pubmed ID
- 9461419
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Reference
- Gene. 1998 Jan 5;206(1):85-91.
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Author
- Huttner KM, Lambeth MR, Burkin HR, Burkin DJ, Broad TE.