General Information
Activity Information
-
Biological Activity
- Antimicrobial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02917.
Physicochemical Information
-
Formula
- C114H182N30O31S8
Absent Amino Acids
- AEMNQRSVWY
Common Amino Acids
- C
Mass
- 2725.36
PI
- 8.21
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 5
Net Charge
- +3
-
Boman Index
- -4.9
Hydrophobicity
- 0.556
Aliphatic Index
- 46.8
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 500
Absorbance 280nm
- 20.83
Polar Residues
- 13
DRAMP02917
![DRAMP02917 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP02917.1.png)
Comments Information
Function
- Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.
PTM
- Contains four disulfide bonds 7-23; 10-13; 11-19; 14-22.
Literature Information
- ·Literature 1
-
Title
- Identification of dog hepcidin.
-
Pubmed ID
- PubMed ID is not available
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Reference
- Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
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Author
- Shi J, Wei Y, Boothe D.
- ·Literature 2
-
Title
- Identification of dog hepcidin in China.
-
Pubmed ID
- PubMed ID is not available
-
Reference
- Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
-
Author
- Li XD, Zhao TZ, Sun M, Tian KG, Chen XZ.