General Information

    • DRAMP ID

    • DRAMP02920

    • Peptide Name

    • Beta-defensin 119 (Defensin, beta 119; dogs, mammals, animals)

    • Source

    • Canis familiaris (Dog)

    • Family

    • Belongs to the glycosyl hydrolase 22 family

    • Gene

    • DEFB119

    • Sequence

    • KHHILRCMGNTGICRPSCRKTEQPYLYCLNYQSCCLQSYMRISISGREEKDDWSQQNRWPKIS

    • Sequence Length

    • 63

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02920 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02920.

Physicochemical Information

    • Formula

    • C322H507N99O95S8

    • Absent Amino Acids

    • AFV

    • Common Amino Acids

    • SCR

    • Mass

    • 7541.65

    • PI

    • 9.06

    • Basic Residues

    • 12

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +7

    • Boman Index

    • -171.89

    • Hydrophobicity

    • -0.921

    • Aliphatic Index

    • 55.71

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 17335

    • Absorbance 280nm

    • 279.6

    • Polar Residues

    • 25

DRAMP02920

DRAMP02920 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity (By similarity).

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

    • Reference

    • Physiol Genomics. 2005 Sep 21;23(1):5-17.

    • Author

    • Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.