General Information

    • DRAMP ID

    • DRAMP02929

    • Peptide Name

    • Antimicrobial protein 1

    • Source

    • Scylla serrata (Mud crab)

    • Family

    • Not found

    • Gene

    • AP

    • Sequence

    • GQALNKLMPKIVSAIIYMIGQPNAGVTFLGHQCLVESTRQPDGFYTAKMWCTSWTSDNPIVGEGRSRVELEALKGSIRNFVQTASDYKKFTIEEVEDWIAS

    • Sequence Length

    • 102

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Escherichia coli (MIC<50 µg/ml), Pseudomonas aeruginosa (MIC<25 µg/ml);
      • Gram-negative bacteria: Staphylococcus aureus (MIC<100 µg/ml), Streptococcus pyogenes (MIC<50 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02929 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02929.

Physicochemical Information

    • Formula

    • C503H785N133O151S5

    • Absent Amino Acids

    • Common Amino Acids

    • GISAETVKL

    • Mass

    • 11271.87

    • PI

    • 5.77

    • Basic Residues

    • 11

    • Acidic Residues

    • 11

    • Hydrophobic Residues

    • 35

    • Net Charge

    • 0

    • Boman Index

    • -13419

    • Hydrophobicity

    • -0.192

    • Aliphatic Index

    • 81.09

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 21095

    • Absorbance 280nm

    • 210.95

    • Polar Residues

    • 32

DRAMP02929

DRAMP02929 chydropathy plot

Comments Information

    • Tissue specificity

    • Strongly expressed in gills, hemocytes and reproductive tract, with weaker expression in muscle, heart and digestive tract. Not detected in eyes and hepatopancreas (at protein level).

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of antibacterial proteins from granular hemocytes of Indian mud crab, Scylla serrata.

    • Reference

    • Acta Biochim Pol. 2009;56(1):71-82.

    • Author

    • Yedery RD, Reddy KV.