General Information

    • DRAMP ID

    • DRAMP02939

    • Peptide Name

    • Tachyplesin-2 (Tachyplesin II; crabs, Arthropods, animals)

    • Source

    • Tachypleus tridentatus (Japanese horseshoe crab)

    • Family

    • Belongs to the tachyplesin/polyphemusin family

    • Gene

    • Not found

    • Sequence

    • RWCFRVCYRGICYRKCR

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

      • Yeast: Candida albicans M9.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation (Arg17)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys3 and Cys16,Cys7 and Cys12.

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02939 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02939.

Physicochemical Information

    • Formula

    • C99H154N34O20S4

    • Absent Amino Acids

    • ADEHLMNPQST

    • Common Amino Acids

    • R

    • Mass

    • 2268.77

    • PI

    • 9.93

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +6

    • Boman Index

    • -60.1

    • Hydrophobicity

    • -0.518

    • Aliphatic Index

    • 40

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8730

    • Absorbance 280nm

    • 545.63

    • Polar Residues

    • 7

DRAMP02939

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity.

    • Reference

    • J Biochem. 1989 Oct;106(4):663-668.

    • Author

    • Miyata T, Tokunaga F, Yonega T, Yoshikawa K, Iwanaga S, Niwa M, Takao T, Shimonishi Y.