• DRAMP ID

    • DRAMP02940
    • Peptide Name

    • Tachyplesin-3 (Tachyplesin III; crabs, Arthropods, animals)
    • Source

    • Tachypleus gigas (Southeast Asian horseshoe crab)
    • Family

    • Belongs to the tachyplesin/polyphemusin family
    • Gene

    • Not found
    • Sequence

    • KWCFRVCYRGICYRKCR
    • Sequence Length

    • 17
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation (Arg17)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys3 and Cys16,Cys7 and Cys12.
    • Stereochemistry

    • L
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02940 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02940.
    • Formula

    • C99H154N32O20S4
    • Absent Amino Acids

    • ADEHLMNPQST
    • Common Amino Acids

    • CR
    • Mass

    • 2240.75
    • PI

    • 9.79
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +6
    • Boman Index

    • -50.73
    • Hydrophobicity

    • -0.482
    • Aliphatic Index

    • 40
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 8730
    • Absorbance 280nm

    • 545.63
    • Polar Residues

    • 7

DRAMP02940

    • Function

    • Significantly inhibits the growth of Gram-negative and Gram-positive bacteria.
    • Tissue specificity

    • Hemocytes.
    • PTM

    • Contains two disulfide bonds 3-16; 7-12, and Arginine amide at R17.
  • ·Literature 1
    • Title

    • Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor.
    • Reference

    • J Biochem. 1990 Aug;108(2):261-266.
    • Author

    • Muta T, Fujimoto T, Nakajima H, Iwanaga S.