General Information

    • DRAMP ID

    • DRAMP02940

    • Peptide Name

    • Tachyplesin-3 (Tachyplesin III; crabs, Arthropods, animals)

    • Source

    • Tachypleus gigas (Southeast Asian horseshoe crab)

    • Family

    • Belongs to the tachyplesin/polyphemusin family

    • Gene

    • Not found

    • Sequence

    • KWCFRVCYRGICYRKCR

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation (Arg17)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys3 and Cys16,Cys7 and Cys12.

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02940 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02940.

Physicochemical Information

    • Formula

    • C99H154N32O20S4

    • Absent Amino Acids

    • ADEHLMNPQST

    • Common Amino Acids

    • CR

    • Mass

    • 2240.75

    • PI

    • 9.79

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +6

    • Boman Index

    • -50.73

    • Hydrophobicity

    • -0.482

    • Aliphatic Index

    • 40

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8730

    • Absorbance 280nm

    • 545.63

    • Polar Residues

    • 7

DRAMP02940

Comments Information

    • Function

    • Significantly inhibits the growth of Gram-negative and Gram-positive bacteria.

    • Tissue specificity

    • Hemocytes.

    • PTM

    • Contains two disulfide bonds 3-16; 7-12, and Arginine amide at R17.

Literature Information

  • ·Literature 1

    • Title

    • Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor.

    • Reference

    • J Biochem. 1990 Aug;108(2):261-266.

    • Author

    • Muta T, Fujimoto T, Nakajima H, Iwanaga S.