General Information
-
DRAMP ID
- DRAMP02940
-
Peptide Name
- Tachyplesin-3 (Tachyplesin III; crabs, Arthropods, animals)
-
Source
- Tachypleus gigas (Southeast Asian horseshoe crab)
-
Family
- Belongs to the tachyplesin/polyphemusin family
-
Gene
- Not found
-
Sequence
- KWCFRVCYRGICYRKCR
-
Sequence Length
- 17
-
UniProt Entry
- P18252
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation (Arg17)
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys3 and Cys16,Cys7 and Cys12.
-
Stereochemistry
- L
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02940.
Physicochemical Information
-
Formula
- C99H154N32O20S4
Absent Amino Acids
- ADEHLMNPQST
Common Amino Acids
- CR
Mass
- 2240.75
PI
- 9.79
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +6
-
Boman Index
- -50.73
Hydrophobicity
- -0.482
Aliphatic Index
- 40
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 8730
Absorbance 280nm
- 545.63
Polar Residues
- 7
DRAMP02940
Comments Information
Function
- Significantly inhibits the growth of Gram-negative and Gram-positive bacteria.
Tissue specificity
- Hemocytes.
PTM
- Contains two disulfide bonds 3-16; 7-12, and Arginine amide at R17.
Literature Information
- ·Literature 1
-
Title
- Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor.
-
Pubmed ID
- 2229025
-
Reference
- J Biochem. 1990 Aug;108(2):261-266.
-
Author
- Muta T, Fujimoto T, Nakajima H, Iwanaga S.