General Information

    • DRAMP ID

    • DRAMP02955

    • Peptide Name

    • Hedistin (marine annelid, Metazoa)

    • Source

    • Hediste diversicolor

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LGAWLAGKVAGTVATYAWNRYV

    • Sequence Length

    • 22

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MRSA);
      • Gram-negative bacterium: Vibrio alginolyticus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02955 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02955.

Physicochemical Information

    • Formula

    • C112H167N29O28

    • Absent Amino Acids

    • CDEFHIMPQS

    • Common Amino Acids

    • A

    • Mass

    • 2367.74

    • PI

    • 9.7

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • 5.96

    • Hydrophobicity

    • 0.468

    • Aliphatic Index

    • 97.73

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 13980

    • Absorbance 280nm

    • 665.71

    • Polar Residues

    • 8

DRAMP02955

DRAMP02955 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Hedistin: A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor.

    • Reference

    • Dev Comp Immunol. 2007;31(8):749-762.

    • Author

    • Tasiemski A, Schikorski D, Le Marrec-Croq F, Pontoire-Van Camp C, Boidin-Wichlacz C, Sautière PE.