General Information

    • DRAMP ID

    • DRAMP02959

    • Peptide Name

    • Antibacterial protein PR-39 (pigs, mammals, animals)

    • Source

    • Sus scrofa (Pig)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • PR39

    • Sequence

    • RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP

    • Sequence Length

    • 39

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli K12 D21 (MIC=0.3 µM), Escherichia coli Bd2221175 (MIC=0.3 µM), Salmonella typhimurium LT2 (MIC=1µM), Proteus vulgaris Pvll (MIC=300 µM), Pseudomonas aeruginosa OT97 (MIC=200 µM), Acinetobacter calcoaceticus Acl 1 (MIC=3 µM).
      • Gram-positive bacteria: Bacillus megaterium (MIC=0.3 µM), Bacillus subtilis (MIC=15 µM), Staphylococcus aureus (MIC=200 µM), Streptococcus pyogenes (MIC=2 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02959 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C229H345N69O41

    • Absent Amino Acids

    • ACDEHKMNQSTVW

    • Common Amino Acids

    • P

    • Mass

    • 4720.7

    • PI

    • 12.6

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +10

    • Boman Index

    • -118.74

    • Hydrophobicity

    • -1.308

    • Aliphatic Index

    • 30

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 39.21

    • Polar Residues

    • 2

DRAMP02959

DRAMP02959 chydropathy plot

Comments Information

    • Tissue specificity

    • Small intestine and bone marrow.

    • PTM

    • Proline amide at P39.

Literature Information

  • ·Literature 1

    • Title

    • Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides.

    • Reference

    • Eur J Biochem. 1991 Dec 18;202(3):849-854.

    • Author

    • Agerberth B, Lee JY, Bergman T, Carlquist M, Boman HG, Mutt V, Jörnvall H.
  • ·Literature 2

    • Title

    • Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39.

    • Reference

    • Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7085-7089.

    • Author

    • Gudmundsson GH, Magnusson KP, Chowdhary BP, Johansson M, Andersson L, Boman HG.