• DRAMP ID

    • DRAMP02964
    • Peptide Name

    • PMAP-36(1-34)
    • Source

    • Sus scrofa (Pig)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLG
    • Sequence Length

    • 34
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1 µM), S. aureus 710A (MIC=2 µM), S. aureus SA-62 (MRSA) (MIC=4 µM), Bacillus megaterium Bm11 (MIC=1 µM), S. epidermidis ATCC 12228 (MIC=1 µM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 µM), E. coli ML35 (MIC=1 µM), E. coli D21 (MIC=1 µM), E. coli D22 (MIC=0.5 µM), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 µM), S. enterica ser. Enteritidis H2 (MIC=1 µM), P. aeruginosa ATCC 27853 (MIC=1 µM), S. marcescens ATCC 8100 (MIC=2 µM).
      • Fungi: Candida albicans c.i. (MIC=8 µM), Cryptococcus neoformans c.i.(MIC=2 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02964 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C186H328N60O37
    • Absent Amino Acids

    • ACDEHMNQY
    • Common Amino Acids

    • K
    • Mass

    • 3997.03
    • PI

    • 12.71
    • Basic Residues

    • 13
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +13
    • Boman Index

    • -77.83
    • Hydrophobicity

    • -0.55
    • Aliphatic Index

    • 108.82
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 166.67
    • Polar Residues

    • 6

DRAMP02964

DRAMP02964 chydropathy plot
    • Function

    • Exerts antimicrobial activity against both Gram-positive and negative bacteria.
  • ·Literature 1
    • Title

    • Structural aspects and biological properties of the cathelicidin PMAP-36.
    • Reference

    • FEBS J. 2005 Sep;272(17):4398-4406.
    • Author

    • Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A.