General Information

    • DRAMP ID

    • DRAMP02968

    • Peptide Name

    • Prophenin-1 (C6, PF-1; Pro-rich; pigs, mammals, animals)

    • Source

    • Sus scrofa (Pig)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • Not found

    • Sequence

    • AFPPPNVPGPRFPPPNFPGPRFPPPNFPGPRFPPPNFPGPRFPPPNFPGPPFPPPIFPGPWFPPPPPFRPPPFGPPRFP

    • Sequence Length

    • 79

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Listeria monocytogenes;
      • Gram-negative bacterium: Escherichia coli.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02968 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02968.

Physicochemical Information

    • Formula

    • C440H589N103O85

    • Absent Amino Acids

    • CDEHKLMQSTY

    • Common Amino Acids

    • P

    • Mass

    • 8681.16

    • PI

    • 12.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 19

    • Net Charge

    • +6

    • Boman Index

    • -58.34

    • Hydrophobicity

    • -0.796

    • Aliphatic Index

    • 9.87

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 70.51

    • Polar Residues

    • 12

DRAMP02968

DRAMP02968 chydropathy plot

Comments Information

    • Function

    • Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes.

    • Reference

    • FEBS Lett. 1995 Mar 27;362(1):65-69.

    • Author

    • Harwig SS, Kokryakov VN, Swiderek KM, Aleshina GM, Zhao C, Lehrer RI.
  • ·Literature 2

    • Title

    • Molecular cloning and identification of a novel porcine cathelin-like antibacterial peptide precursor.

    • Reference

    • Biol Chem Hoppe Seyler. 1995 Aug;376(8):507-510.

    • Author

    • Strukelj B, Pungercar J, Kopitar G, Renko M, Lenarcic B, Berbić S, Turk V.