General Information

    • DRAMP ID

    • DRAMP02969

    • Peptide Name

    • Prophenin-2 (C12, PF-2, PR-2; Pro-rich; pigs, mammals, animals)

    • Source

    • Sus scrofa (Pig)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • Not found

    • Sequence

    • AFPPPNVPGPRFPPPNVPGPRFPPPNFPGPRFPPPNFPGPRFPPPNFPGPPFPPPIFPGPWFPPPPPFRPPPFGPPRFP

    • Sequence Length

    • 79

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Listeria monocytogenes;
      • Gram-negative bacterium: Escherichia coli.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02969 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02969.

Physicochemical Information

    • Formula

    • C436H589N103O85

    • Absent Amino Acids

    • CDEHKLMQSTY

    • Common Amino Acids

    • P

    • Mass

    • 8633.11

    • PI

    • 12.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 19

    • Net Charge

    • +6

    • Boman Index

    • -57.28

    • Hydrophobicity

    • -0.779

    • Aliphatic Index

    • 13.54

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 70.51

    • Polar Residues

    • 12

DRAMP02969

DRAMP02969 chydropathy plot

Comments Information

    • Function

    • Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Molecular cloning of a putative homolog of proline/arginine-rich antibacterial peptides from porcine bone marrow.

    • Reference

    • FEBS Lett. 1993 Dec 27;336(2):284-288.

    • Author

    • Pungercar J, Strukelj B, Kopitar G, Renko M, Lenarcic B, Gubensek F, Turk V.
  • ·Literature 2

    • Title

    • Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39.

    • Reference

    • FEBS Lett. 1995 Dec 4;376(3):130-134.

    • Author

    • Zhao C, Ganz T, Lehrer RI.