• DRAMP ID

    • DRAMP02972
    • Peptide Name

    • Protegrin-3 (Protegrin 3; PG-3; pigs, mammals, animals)
    • Source

    • Sus scrofa (Pig)
    • Family

    • Belongs to the cathelicidin family
    • Gene

    • NPG3
    • Sequence

    • RGGGLCYCRRRFCVCVGR
    • Sequence Length

    • 18
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacterium: Listeria moncyrogenes strain EGD;
      • Gram-negative bacterium: Escherichia coli ML-35.
      • Yeast: Candida albicans strain 820.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02972 helical wheel diagram
    • PDB ID

    • 2MZ6 resolved by NMR.
  • 2MZ6-> 
    • Predicted Structure

    • There is no predicted structure for DRAMP02972.
    • Formula

    • C84H141N33O20S4
    • Absent Amino Acids

    • ADEHIKMNPQSTW
    • Common Amino Acids

    • R
    • Mass

    • 2061.49
    • PI

    • 9.88
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +5
    • Boman Index

    • -49.88
    • Hydrophobicity

    • -0.022
    • Aliphatic Index

    • 53.89
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1740
    • Absorbance 280nm

    • 102.35
    • Polar Residues

    • 9

DRAMP02972

DRAMP02972 chydropathy plot
    • Function

    • Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.
    • PTM

    • Probablely contains two disulfide bonds 6-15; 8-13 and Arginine amide at R18.
  • ·Literature 1
    • Title

    • Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.
    • Reference

    • FEBS Lett. 1993 Jul 26;327(2):231-236.
    • Author

    • Kokryakov VN, Harwig SS, Panyutich EA, Shevchenko AA, Aleshina GM, Shamova OV, Korneva HA, Lehrer RI.