General Information

    • DRAMP ID

    • DRAMP02972

    • Peptide Name

    • Protegrin-3 (Protegrin 3; PG-3; pigs, mammals, animals)

    • Source

    • Sus scrofa (Pig)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • NPG3

    • Sequence

    • RGGGLCYCRRRFCVCVGR

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Listeria moncyrogenes strain EGD;
      • Gram-negative bacterium: Escherichia coli ML-35.
      • Yeast: Candida albicans strain 820.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02972 helical wheel diagram

    • PDB ID

    • 2MZ6 resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP02972.

Physicochemical Information

    • Formula

    • C84H141N33O20S4

    • Absent Amino Acids

    • ADEHIKMNPQSTW

    • Common Amino Acids

    • R

    • Mass

    • 2061.49

    • PI

    • 9.88

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +5

    • Boman Index

    • -49.88

    • Hydrophobicity

    • -0.022

    • Aliphatic Index

    • 53.89

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1740

    • Absorbance 280nm

    • 102.35

    • Polar Residues

    • 9

DRAMP02972

DRAMP02972 chydropathy plot

Comments Information

    • Function

    • Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

    • PTM

    • Probablely contains two disulfide bonds 6-15; 8-13 and Arginine amide at R18.

Literature Information

  • ·Literature 1

    • Title

    • Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.

    • Reference

    • FEBS Lett. 1993 Jul 26;327(2):231-236.

    • Author

    • Kokryakov VN, Harwig SS, Panyutich EA, Shevchenko AA, Aleshina GM, Shamova OV, Korneva HA, Lehrer RI.