General Information

    • DRAMP ID

    • DRAMP02973

    • Peptide Name

    • Protegrin-4 (Protegrin 4; PG-4; pigs, mammals, animals)

    • Source

    • Sus scrofa (Pig)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • NPG4

    • Sequence

    • RGGRLCYCRGWICFCVGR

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02973 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02973.

Physicochemical Information

    • Formula

    • C90H141N31O20S4

    • Absent Amino Acids

    • ADEHKMNPQST

    • Common Amino Acids

    • CGR

    • Mass

    • 2105.55

    • PI

    • 9.37

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +4

    • Boman Index

    • -31.75

    • Hydrophobicity

    • 0.194

    • Aliphatic Index

    • 59.44

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 7240

    • Absorbance 280nm

    • 425.88

    • Polar Residues

    • 9

DRAMP02973

DRAMP02973 chydropathy plot

Comments Information

    • Function

    • Microbicidal activity (By similarity).

    • PTM

    • Contains two disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Identification of a new member of the protegrin family by cDNA cloning.

    • Reference

    • FEBS Lett. 1994; 346: 285-288.

    • Author

    • Zhao C, Liu L, Lehrer RI.
  • ·Literature 2

    • Title

    • NMR structure of the cathelin-like domain of the protegrin-3 precursor.

    • Reference

    • ochemistry. 2003 Apr 29;42(16):4669-4680.

    • Author

    • Yang Y, Sanchez JF, Strub MP, Brutscher B, Aumelas A.