General Information
-
DRAMP ID
- DRAMP02974
-
Peptide Name
- Protegrin-5 (Protegrin 5; PG-5; pigs, mammals, animals)
-
Source
- Sus scrofa (Pig)
-
Family
- Belongs to the cathelicidin family
-
Gene
- NPG5
-
Sequence
- RGGRLCYCRPRFCVCVGR
-
Sequence Length
- 18
-
UniProt Entry
- P49934
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02974.
Physicochemical Information
-
Formula
- C87H145N33O20S4
Absent Amino Acids
- ADEHIKMNQSTW
Common Amino Acids
- R
Mass
- 2101.56
PI
- 9.88
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +5
-
Boman Index
- -50.82
Hydrophobicity
- -0.089
Aliphatic Index
- 53.89
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 1740
Absorbance 280nm
- 102.35
Polar Residues
- 8
DRAMP02974
![DRAMP02974 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP02974.1.png)
Comments Information
Function
- Microbicidal activity (By similarity).
PTM
- Contains two disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- The structure of porcine protegrin genes.
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Pubmed ID
- 7628604
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Reference
- FEBS Lett. 1995 Jul 17;368(2):197-202.
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Author
- Zhao C, Ganz T, Lehrer RI.