General Information

    • DRAMP ID

    • DRAMP02975

    • Peptide Name

    • Tritrpticin (Trp-rich; pigs, mammals, animals)

    • Source

    • Sus scrofa (Pig)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • Not found

    • Sequence

    • VRRFPWWWPFLRR

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (5 mm), Pseudomonas aeruginosa (3 mm), Klebsiella pneumonia (7 mm), Proteus mirabilis (1 mm);
      • Gram-positive bacteria: Staphylococcus epidermidis (5 mm), Streptococcus group D (4 mm). [inhibit zones in mm]
      • Fungi: Aspergillus fumigatus (MIC=250 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix (1 helices; 3 residues)

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02975 helical wheel diagram

    • PDB ID

    • 1D6X resolved by NMR.
  • 1D6X-> 

    • Predicted Structure

    • There is no predicted structure for DRAMP02975.

Physicochemical Information

    • Formula

    • C96H132N28O14

    • Absent Amino Acids

    • ACDEGHIKMNQSTY

    • Common Amino Acids

    • R

    • Mass

    • 1902.28

    • PI

    • 12.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • -37.77

    • Hydrophobicity

    • -0.792

    • Aliphatic Index

    • 52.31

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 16500

    • Absorbance 280nm

    • 1375

    • Polar Residues

    • 0

DRAMP02975

Comments Information

    • Function

    • Tritrpticin has strong antimicrobial activity with a wide spectrum.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides.

    • Reference

    • FEBS Lett. 1996 Jul 15;390(1):95-98.

    • Author

    • Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K.Schibli DJ, Hwang PM, Vogel HJ.
  • ·Literature 2

    • Title

    • Structure of the antimicrobial peptide tritrpticin bound to micelles: a distinct membrane-bound peptide fold.

    • Reference

    • Biochemistry. 1999 Dec 21;38(51):16749-55.

    • Author

    • Schibli DJ, Hwang PM, Vogel HJ.