General Information

    • DRAMP ID

    • DRAMP02978

    • Peptide Name

    • pBD-2 (porcine beta-defensin 2; pigs, mammals, animals)

    • Source

    • Sus scrofa (Pig)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DHYICAKKGGTCNFSPCPLFNRIEGTCYSGKAKCCIR

    • Sequence Length

    • 37

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Salmonella typhimurium, Listeria monocytogenes and Erysipelothrix rhusiopathiae.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Combine helix and strand structure

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02978 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02978.

Physicochemical Information

    • Formula

    • C175H275N51O50S6

    • Absent Amino Acids

    • MQVW

    • Common Amino Acids

    • C

    • Mass

    • 4085.78

    • PI

    • 8.89

    • Basic Residues

    • 7

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +5

    • Boman Index

    • -57.03

    • Hydrophobicity

    • -0.289

    • Aliphatic Index

    • 47.57

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 93.19

    • Polar Residues

    • 18

DRAMP02978

DRAMP02978 chydropathy plot

Comments Information

    • Thought to be orthologue of hBD-1. The native pBD-2 has NOT been purified yet, so it's unclear to what extent the synthetic peptide corresponds to the in vivo form. Also of note is that the synthetic peptide does not have S-S bonds. pBD-2 (4-8 microM) killed these pathogens within 3h. Antimicrobial activity of pBD-2 was decreased at higher ionic strengths with no residual activity at 150mM NaCl.

Literature Information

  • ·Literature 1

    • Title

    • Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria.

    • Reference

    • Mol Immunol. 2008 Jan;45(2):386-394.

    • Author

    • Veldhuizen EJ, Rijnders M, Claassen EA, van Dijk A, Haagsman HP.