• DRAMP ID

    • DRAMP02981
    • Peptide Name

    • Liver-expressed antimicrobial peptide 2 (LEAP-2; pigs, mammals, animals)
    • Source

    • Sus scrofa (Pig)
    • Family

    • Belongs to the LEAP2 family
    • Gene

    • LEAP2
    • Sequence

    • MTPFWRAVSLRPIGASCRDDSECLTRLCRKRRCSLSVAQE
    • Sequence Length

    • 40
    • Protein Existence

    • Homology
    • Biological Activity

    • Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02981 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02981.
    • Formula

    • C192H322N64O57S5
    • Absent Amino Acids

    • HNY
    • Common Amino Acids

    • R
    • Mass

    • 4599.36
    • PI

    • 9.37
    • Basic Residues

    • 8
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +4
    • Boman Index

    • -116.9
    • Hydrophobicity

    • -0.365
    • Aliphatic Index

    • 70.75
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5750
    • Absorbance 280nm

    • 147.44
    • Polar Residues

    • 12

DRAMP02981

DRAMP02981 chydropathy plot
    • PTM

    • Contains two disulfide bonds 17-28; 23-33.
  • ·Literature 1
    • Title

    • Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver.
    • Reference

    • Protein Sci. 2003 Jan;12(1):143-152.
    • Author

    • Krause A, Sillard R, Kleemeier B, Klüver E, Maronde E, Conejo-García JR, Forssmann WG, Schulz-Knappe P, Nehls MC, Wattler F, Wattler S, Adermann K.