General Information
-
DRAMP ID
- DRAMP02982
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Peptide Name
- Reactive oxygen species modulator 1 (ROS modulator 1; pigs, mammals, animals)
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Source
- Sus scrofa (Pig)
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Family
- Belongs to the MGR2 family
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Gene
- romo1
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Sequence
- MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGPFSCLRIGMRGRELMGGIGKTMMQSGGTFGPFMAIGMGIRC
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Sequence Length
- 79
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UniProt Entry
- A1XQR6
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus, Mycobacterium tuberculosis;
- Gram-negative bacterium: Pseudomonas aeruginosa.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02982.
Physicochemical Information
-
Formula
- C355H567N99O94S14
Absent Amino Acids
- HNW
Common Amino Acids
- G
Mass
- 8174.85
PI
- 9.58
Basic Residues
- 7
Acidic Residues
- 2
Hydrophobic Residues
- 24
Net Charge
- +5
-
Boman Index
- -8.75
Hydrophobicity
- 0.487
Aliphatic Index
- 60.51
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1740
Absorbance 280nm
- 22.31
Polar Residues
- 28
DRAMP02982
![DRAMP02982 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP02982.1.png)
Comments Information
Function
- Has antibacterial activity against a variety of bacteria. Acts by inducing bacterial membrane breakage (By similarity).
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).
Domain
- Contains a transmembrane helix.
Literature Information
- ·Literature 1
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Title
- Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library.
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Pubmed ID
- PubMed ID is not available
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Reference
- Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
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Author
- Cai G, Chen Y, Wang C, Li J, Peng G, Zhang H.