• DRAMP ID

    • DRAMP02989
    • Peptide Name

    • Lasioglossin LL-I (Insects, animals)
    • Source

    • Lasioglossum laticeps (Eusocial Bee)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • VNWKKVLGKIIKVAK
    • Sequence Length

    • 15
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer
    • Target Organism

      • [Ref.19591185]Gram-positive bacteria: B. subtilis(MIC=0.8 μM), S. aureus(MIC=14.3 μM);
      • Gram-negative bacteria: P. aeruginosa(MIC=15.8 μM), E. coli(MIC=1.7 μM).
    • Hemolytic Activity

      • [Ref.19591185]LC50>200 μM against rat red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02989 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02989.
    • Formula

    • C83H146N22O17
    • Absent Amino Acids

    • CDEFHMPQRSTY
    • Common Amino Acids

    • K
    • Mass

    • 1724.21
    • PI

    • 10.6
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +5
    • Boman Index

    • -2.43
    • Hydrophobicity

    • 0.193
    • Aliphatic Index

    • 142.67
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 392.86
    • Polar Residues

    • 2

DRAMP02989

    • Function

    • Active against B. subtilis, S. aureus, P. aeruginosa, and E. coli. Low hemolytic toxicity.
  • ·Literature 1
    • Title

    • Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
    • Reference

    • Chembiochem. 2009 Aug 17;10(12):2089-2099.
    • Author

    • Cerovský V, Budesínský M, Hovorka O, Cvacka J, Voburka Z, Slaninová J, Borovicková L, Fucík V, Bednárová L, Votruba I, Straka J.