General Information

    • DRAMP ID

    • DRAMP02992

    • Peptide Name

    • Lasiocepsin (Insects, animals)

    • Source

    • Lasioglossum laticeps (Eusocial Bee)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLPRKILCAIAKKKGKCKGPLKLVCKC

    • Sequence Length

    • 27

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.22038181]LC50>200 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02992 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP02992.

Physicochemical Information

    • Formula

    • C129H238N38O28S4

    • Absent Amino Acids

    • DEFHMNQSTWY

    • Common Amino Acids

    • K

    • Mass

    • 2897.79

    • PI

    • 10.07

    • Basic Residues

    • 9

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +9

    • Boman Index

    • -14.2

    • Hydrophobicity

    • 0.07

    • Aliphatic Index

    • 104.81

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 9.62

    • Polar Residues

    • 7

DRAMP02992

DRAMP02992 chydropathy plot

Comments Information

    • Function

    • The synthetic lasiocepsin possessed antimicrobial activity against both Gram-positive and -negative bacteria, antifungal activity against Candida albicans, and weak hemolytic activity against human erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).

    • Reference

    • Amino Acids. 2012 Aug;43(2):751-761.

    • Author

    • Monincová L, Slaninová J, Fucík V, Hovorka O, Voburka Z, Bednárová L, Malon P, Stokrová J, Cerovský V.