General Information
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 µg/ml), Erwinia salicis (MIC=0.02 µg/ml), Escherichia coli (MIC=0.1 µg/ml), Pseudomonas syringae (MIC=0.2 µg/ml), Rhizobium meliloti (MIC=0.1 µg/ml), Salmonella Newport (MIC=0.2 µg/ml), Salmonella typhimurium (MIC=0.1 µg/ml), Shigella flexneri (MIC=0.1 µg/ml);
- Gram-positive bacteria: Corynebacterium insidiosum (MIC=50 µg/ml), Bacillus megaterium (MIC=150 µg/ml)
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP02998_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C95H150N32O23
Absent Amino Acids
- ACDEFKLMSTW
Common Amino Acids
- P
Mass
- 2108.44
PI
- 11.71
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 3
Net Charge
- +4
-
Boman Index
- -53.56
Hydrophobicity
- -1.406
Aliphatic Index
- 59.44
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 87.65
Polar Residues
- 4
DRAMP02998
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Apidaecins: antibacterial peptides from honeybees.
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Pubmed ID
- 2676519
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Reference
- EMBO J. 1989 Aug;8(8):2387-2391.
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Author
- Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P.