General Information

    • DRAMP ID

    • DRAMP03001

    • Peptide Name

    • Jellein-3 (Jelleine-III; Insects, animals)

    • Source

    • Apis mellifera (Honeybee)

    • Family

    • Not found

    • Gene

    • MRJP1

    • Sequence

    • EPFKISIHL

    • Sequence Length

    • 9

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=30 µg/ml), S. saprophyticus (MIC=30 µg/ml);
      • Gram-negative bacteria: Escherichia coli CCT1371 (MIC=15 µg/ml), Enterobacter cloacae ATCC 23355, Klebsiella pneumoniae ATCC 13883, Pseudomonas aeruginosa ATCC 27853 (MIC=30 µg/ml).
      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03001 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03001.

Physicochemical Information

    • Formula

    • C52H82N12O13

    • Absent Amino Acids

    • ACDGMNQRTVWY

    • Common Amino Acids

    • I

    • Mass

    • 1083.3

    • PI

    • 6.85

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +1

    • Boman Index

    • -2.68

    • Hydrophobicity

    • 0.289

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP03001

Comments Information

    • Function

    • Jellein-3 has antibacterial and antifungal activity.

    • Tissue specificity

    • Found in the hypopharyngeal glands of the worker honeybee.

    • PTM

    • Leucine amide at L9.

Literature Information

  • ·Literature 1

    • Title

    • Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).

    • Reference

    • Peptides. 2004 Jun;25(6):919-928.

    • Author

    • ntana R, Mendes MA, de Souza BM, Konno K, César LM, Malaspina O, Palma MS.