General Information

    • DRAMP ID

    • DRAMP03005

    • Peptide Name

    • Apidaecin (Insects, animals)

    • Source

    • Bombus pascuorum (Brown bumblebee)

    • Family

    • Belongs to the apidaecin family

    • Gene

    • Not found

    • Sequence

    • GNRPVYIPPPRPPHPRL

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Micrococcus luteus;
      • Gram-negative bacteria: Escherichia coli D22.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03005 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03005.

Physicochemical Information

    • Formula

    • C91H143N29O20

    • Absent Amino Acids

    • ACDEFKMQSTW

    • Common Amino Acids

    • P

    • Mass

    • 1963.32

    • PI

    • 11.71

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +4

    • Boman Index

    • -41.38

    • Hydrophobicity

    • -1.212

    • Aliphatic Index

    • 62.94

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 93.13

    • Polar Residues

    • 3

DRAMP03005

Comments Information

    • Function

    • Antibacterial peptide against Gram-positive and Gram-negative bacteria.

    • Induction

    • By bacterial infection.

Literature Information

  • ·Literature 1

    • Title

    • Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea).

    • Reference

    • Insect Biochem Mol Biol. 1997 May;27(5):413-422.

    • Author

    • Rees JA, Moniatte M, Bulet P.