• DRAMP ID

    • DRAMP03017
    • Peptide Name

    • VESP-VB1 (Insects, animals)
    • Source

    • vespine wasps Vespa bicolor
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • FMPIIGRLMSGSL
    • Sequence Length

    • 13
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.18723059] Gram-negative bacterium: Escherichia coli ATCC25922(MIC=7.5μg/ml), Escherichia coli 23A(MIC=7.5μg/ml), Escherichia coli 27A(MIC=15.0μg/ml), Pseudemonas aeruginosa 3A(MIC=3.75μg/ml), Pseudemonas aeruginosa 7A(MIC=3.75μg/ml), ;
      • Gram-positive bacterium: Staphylococcus aureus ATCC2592(MIC=1.9μg/ml), Staphylococcus aureus 6A(MIC=3.75μg/ml), Staphylococcus aureus 15A(MIC=1.0μg/ml);
      • Fungus: Candida albicans ATCC2002(MIC=30.0μg/ml)
    • Hemolytic activity

      • [Ref.18723059] VESP-VB1 had a little hemolytic activity of 10.2% against rabbit red blood cells, and of 3.2% against human red blood cells with peptide concentration up to 200 μg/ml
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknownn
    • DRAMP03017 helical wheel diagram
    • Formula

    • C64H108N16O16S2
    • Absent Amino Acids

    • ACDEHKNQTVWY
    • Common Amino Acids

    • GILMS
    • Mass

    • 1636
    • PI

    • 10.55
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Boman Index

    • 7.52
    • Hydrophobicity

    • 113.08
    • Aliphatic Index

    • 120
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP03017

    • Function

    • Has antimicrobial activities against standard strains and strong antimicrobial ability against drug-resistant strains. Among the tested drug-resistant strains, Pseudemonas aeruginosa and Staphylococcus aureus were the most sensitive for this kind of antimicrobial peptide. Has a little hemolytic activity.
  • Literature 1
    • Reference

    • Peptides. 2008 Nov;29(11):1887-1892.
    • Author

    • Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, Yu H.
    • Title

    • Antimicrobial peptides from the venoms of Vespa bicolor Fabricius.