• • DRAMP ID

  • DRAMP03017

• • Peptide Name

  • VESP-VB1 (Insects, animals)

• • Source

  • vespine wasps Vespa bicolor

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • FMPIIGRLMSGSL

• • Sequence Length

  • 13

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.18723059] Gram-negative bacterium: Escherichia coli ATCC25922(MIC=7.5μg/ml), Escherichia coli 23A(MIC=7.5μg/ml), Escherichia coli 27A(MIC=15.0μg/ml), Pseudemonas aeruginosa 3A(MIC=3.75μg/ml), Pseudemonas aeruginosa 7A(MIC=3.75μg/ml), ;
    • Gram-positive bacterium: Staphylococcus aureus ATCC2592(MIC=1.9μg/ml), Staphylococcus aureus 6A(MIC=3.75μg/ml), Staphylococcus aureus 15A(MIC=1.0μg/ml);
    • Fungus: Candida albicans ATCC2002(MIC=30.0μg/ml)

• • Hemolytic Activity

  • • [Ref.18723059] VESP-VB1 had a little hemolytic activity of 10.2% against rabbit red blood cells, and of 3.2% against human red blood cells with peptide concentration up to 200 μg/ml

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP03017.

DRAMP03017

• • Function

  • Has antimicrobial activities against standard strains and strong antimicrobial ability against drug-resistant strains. Among the tested drug-resistant strains, Pseudemonas aeruginosa and Staphylococcus aureus were the most sensitive for this kind of antimicrobial peptide. Has a little hemolytic activity.

• ·Literature 1

• • Title

  • Antimicrobial peptides from the venoms of Vespa bicolor Fabricius.

• • Pubmed ID

  • 18723059

• • Reference

  • Peptides. 2008 Nov;29(11):1887-1892.

• • Author

  • Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, Yu H.