General Information

    • DRAMP ID

    • DRAMP03023

    • Peptide Name

    • Mastoparan (Protonectarina-MP; Insects, animals)

    • Source

    • Protonectarina sylveirae (Brazilian wasp)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • INWKALLDAAKKVL

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

    • [Swiss_Prot Entry P0C1Q5]Potent antimicrobial peptide against both Gram-positive and Gram-negative bacteria (By similarity)

    • Hemolytic Activity

      • [Ref.20108158]ED50 =3.4 × 10−5 M against rat red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03023 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03023.

Physicochemical Information

    • Formula

    • C75H127N19O18

    • Absent Amino Acids

    • CEFGHMPQRSTY

    • Common Amino Acids

    • AKL

    • Mass

    • 1582.95

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • -0.53

    • Hydrophobicity

    • 0.421

    • Aliphatic Index

    • 153.57

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 1

DRAMP03023

Comments Information

    • Function

    • Shows potent antimicrobial action against both Gram-positive and Gram-negative bacteria By similarity. This peptide shows potent histamine releasing activities on rat peritoneal mast cells. Also Has hemolytic and cytolytic activity.

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-terminal amidation (Leucine amide

Literature Information

  • ·Literature 1

    • Title

    • Isolation and sequence analysis of peptides from the venom of Protonectarina sylveirae (Hymenoptera-Vespidae).

    • Reference

    • Nat Toxins. 1993;1(5):271-276.

    • Author

    • Dohtsu K, Okumura K, Hagiwara K, Palma MS, Nakajima T.
  • ·Literature 2

    • Title

    • Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).

    • Reference

    • Toxicon. 2010 Apr 1;55(4):711-718.

    • Author

    • Baek JH, Lee SH.
  • ·Literature 3

    • Title

    • Investigating the effect of different positioning of lysine residues along the peptide chain of mastoparans for their secondary structures and biological activities.

    • Reference

    • Amino Acids. 2011 Jan;40(1):77-90.

    • Author

    • de Souza BM, Dos Santos Cabrera MP, Neto JR, Palma MS.