General Information

    • DRAMP ID

    • DRAMP03025

    • Peptide Name

    • Mastoparan M

    • Source

    • Vespa magnifica

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • INLKAIAALAKKLL

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-

    • Target Organism

      • [Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=6.0 ± 3.5 mg/L, MBC=6.0 ± 3.5 mg/L), Enterococcus faecalis isolates(MIC=5.3 ± 2.3 mg/L, MBC=6.7 ± 2.3 mg/L);
      • Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=4.0 ± 3.5 mg/L, MBC=4.7 ± 3.0 mg/L), Acinetobacter baumannii isolates(MIC=2.7 ± 1.2 mg/L, MBC=3.3 ± 1.2 mg/L)

    • Hemolytic Activity

      • [Ref.27591703] 0% hemolysis at 64 μg/ml against human red blood cells; 0% hemolysis at 32 μg/ml , 6% hemolysis at 64 μg/ml against sheep red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03025 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03025.

Physicochemical Information

    • Formula

    • C70H130N18O16

    • Absent Amino Acids

    • CDEFGHMPQRSTVWY

    • Common Amino Acids

    • AL

    • Mass

    • 1479.91

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • 13.47

    • Hydrophobicity

    • 1.157

    • Aliphatic Index

    • 195.71

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP03025

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • A synthesized cationic tetradecapeptide from hornet venom kills bacteria and neutralizes lipopolysaccharide in vivo and in vitro.

    • Reference

    • Biochem Pharmacol. 2005 Jul 15;70(2):209-219.

    • Author

    • Yibin G, Jiang Z, Hong Z, Gengfa L, Liangxi W, Guo W, Yongling L.
  • ·Literature 2

    • Title

    • Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B.

    • Reference

    • Chem Biol Drug Des. 2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864.

    • Author

    • Memariani H, Shahbazzadeh D, Ranjbar R, Behdani M, Memariani M, Pooshang Bagheri K