General Information

    • DRAMP ID

    • DRAMP03028

    • Peptide Name

    • Polybia-MP1

    • Source

    • Polybia paulista

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IDWKKLLDAAKQIL

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.29075946] Gram-positive bacterium: Bacillus subtilis (MIC=12.5μM), Staphylococcus aureus (MIC=18.8μM);
      • Gram-negative bacterium:Escherichia coli (MIC=75μM), Shigella dysenteriae (MIC=75μM), Klebsiella pneumoniae (MIC=37.5μM)

    • Hemolytic Activity

      • [Ref.29075946] <1% hemolysis at 12.5μM, 3.2% hemolysis at 25μM against human red blood cells.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • stapled peptide

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • tethers Lys6 and Arg10

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03028 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C78H131N19O20

    • Absent Amino Acids

    • CEFGHMNPRSTVY

    • Common Amino Acids

    • KL

    • Mass

    • 1655.01

    • PI

    • 8.5

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • -9.08

    • Hydrophobicity

    • 0.064

    • Aliphatic Index

    • 153.57

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 0

DRAMP03028

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity and stability of stapled helices of polybia-MP1

    • Reference

    • Arch Pharm Res. 2017 Dec;40(12):1414-1419.

    • Author

    • Luong HX, Kim DH, Lee BJ, Kim YW