General Information

    • DRAMP ID

    • DRAMP03031

    • Peptide Name

    • Mastoparan-T (Insects, animals)

    • Source

    • Vespa tropica (Greater banded hornet) (Sphex tropica)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • INLKAIAAFAKKLL

    • Sequence Length

    • 14

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03031 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03031.

Physicochemical Information

    • Formula

    • C73H128N18O16

    • Absent Amino Acids

    • CDEGHMPQRSTVWY

    • Common Amino Acids

    • A

    • Mass

    • 1513.93

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • 11.53

    • Hydrophobicity

    • 1.086

    • Aliphatic Index

    • 167.86

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP03031

Comments Information

    • Function

    • Chemotactic peptide for polymorphonucleated leukocytes (PMNL), but causing no hemolysis to rat erythrocytes and no mast cell degranulation activity at physiological concentrations.

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-terminal amidation (Leucine amide

Literature Information

  • ·Literature 1

    • Title

    • Inflammatory role of two venom components of yellow jackets (Vespula vulgaris): a mast cell degranulating peptide mastoparan and phospholipase A1.

    • Reference

    • Int Arch Allergy Immunol. 2003 May;131(1):25-32.

    • Author

    • King T.P, Jim S.Y, Wittkowski K.M.