General Information
-
DRAMP ID
- DRAMP03032
-
Peptide Name
- Mastoparan-A (Insects, animals)
-
Source
- Vespa analis (Yellow-vented hornet)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- IKWKAILDAVKKVL
-
Sequence Length
- 14
-
UniProt Entry
- P0C1Q6
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03032.
Physicochemical Information
-
Formula
- C79H137N19O17
Absent Amino Acids
- CEFGHMNPQRSTY
Common Amino Acids
- K
Mass
- 1625.07
PI
- 10
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 9
Net Charge
- +3
-
Boman Index
- 2.79
Hydrophobicity
- 0.614
Aliphatic Index
- 167.14
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 423.08
Polar Residues
- 0
DRAMP03032
Comments Information
Function
- Chemotactic peptide for polymorphonucleated leukocytes (PMNL), but causing no hemolysis to erythrocytes and no mast cell degranulation activity at physiological concentrations. Potent antimicrobial peptide against both Gram-positive and Gram-negative bacteria.
Tissue specificity
- Expressed by the venom gland.
PTM
- C-terminal amidation (Leucine amide
Literature Information
- ·Literature 1
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Title
- Inflammatory role of two venom components of yellow jackets (Vespula vulgaris): a mast cell degranulating peptide mastoparan and phospholipase A1.
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Pubmed ID
- 12759486
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Reference
- Int Arch Allergy Immunol. 2003 May;131(1):25-32.
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Author
- King T.P, Jim S.Y, Wittkowski K.M.